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Steve Hsu

Manifold

A Natural Sciences , Science and Life Sciences podcast

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About the show

Steve Hsu is Professor of Theoretical Physics and Computational Mathematics, Science, and Engineering at Michigan State University. Join him for wide-ranging conversations with leading writers, scientists, technologists, academics, entrepreneurs, investors, and more.

Newest episodes

Machine God at the University of Chicago– #124

58 min

The student AI club sponsored a private screening of Machine God on Oct 24, 2026. This is the Q&A, led by Sohan Hormuzdiar. Chapter Markers: (00:00) - Meeting Nick Land (02:25) - Andreessen and Accelerationism (05:06) - Philosophy Meets AI (17:06) - Doomers Dreamers and Control (30:13) - Why Make This Film (32:59) - AI As New Religion (35:12) - Techno Capital And Acceleration (47:20) - Alignment Careers And Closing Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring! https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above. – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its cu...

AI and Mathematics, from Beijing – #123

36 min

Special episode recorded in Beijing. Steve discusses the future of mathematics in light of recent AI breakthroughs, the state of AI in China, and some thoughts on China's innovation economy. Chapter Markers: (00:00) - Beijing walk (03:44) - OpenAI Shocks Math World (07:11) - Will Humans Quit Math (11:01) - Tao Versus Yau Visions (12:38) - Building Hard Math Data (13:56) - China AI Ecosystem, US AI bubble and P (Doom) (15:58) - US-China AI competition (21:52) - Hangzhou meeting and financial markets –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

AI Boom or Bust? – #122

39 min

Are we in an AI bubble?  Steve reviews analysis on CapEx, AI revenues, OAI+ANT burn rates. AI revenue has to reach $trillions per annum within the next few years (an increase of > 10x; compare total global software revenue of $1.5T today), or else the current CapEx spend will turn out to be a huge misallocation.  Separately, even if total AI revenue reaches these levels, OAI and ANT could still be overvalued due to revenue/margin compression from competition with other US or Chinese labs.  Chapter Markers: (00:00) - Conference Takeaways (03:21) - AI Capability Leap (07:36) - Both Things True (08:46) - CapEx Debt Risks (10:31) - Trillion Revenue Hurdle (18:32) - Spend Plateau Signals (31:45) - IPO and Bubble Fallout – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs...

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All episodes

Machine God at the University of Chicago– #124

58 min

The student AI club sponsored a private screening of Machine God on Oct 24, 2026. This is the Q&A, led by Sohan Hormuzdiar. Chapter Markers: (00:00) - Meeting Nick Land (02:25) - Andreessen and Accelerationism (05:06) - Philosophy Meets AI (17:06) - Doomers Dreamers and Control (30:13) - Why Make This Film (32:59) - AI As New Religion (35:12) - Techno Capital And Acceleration (47:20) - Alignment Careers And Closing Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring! https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above. – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its cu...

AI and Mathematics, from Beijing – #123

36 min

Special episode recorded in Beijing. Steve discusses the future of mathematics in light of recent AI breakthroughs, the state of AI in China, and some thoughts on China's innovation economy. Chapter Markers: (00:00) - Beijing walk (03:44) - OpenAI Shocks Math World (07:11) - Will Humans Quit Math (11:01) - Tao Versus Yau Visions (12:38) - Building Hard Math Data (13:56) - China AI Ecosystem, US AI bubble and P (Doom) (15:58) - US-China AI competition (21:52) - Hangzhou meeting and financial markets –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

AI Boom or Bust? – #122

39 min

Are we in an AI bubble?  Steve reviews analysis on CapEx, AI revenues, OAI+ANT burn rates. AI revenue has to reach $trillions per annum within the next few years (an increase of > 10x; compare total global software revenue of $1.5T today), or else the current CapEx spend will turn out to be a huge misallocation.  Separately, even if total AI revenue reaches these levels, OAI and ANT could still be overvalued due to revenue/margin compression from competition with other US or Chinese labs.  Chapter Markers: (00:00) - Conference Takeaways (03:21) - AI Capability Leap (07:36) - Both Things True (08:46) - CapEx Debt Risks (10:31) - Trillion Revenue Hurdle (18:32) - Spend Plateau Signals (31:45) - IPO and Bubble Fallout – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs...

Effort News and AI-Driven Journalism with Brian Chau – #121

1 hr 11 min

Brian Chau is a mathematician, machine learning specialist, and the founder of Effort News, an independent media outlet focused on data-first, document-led investigative journalism. https://www.effort.news/ https://x.com/brianchau57 Chapter Markers: (00:00) - Intro (03:14) - Network School Fallout (14:17) - Effort News Origins (17:24) - AI Reporting Workflow (35:41) - Medicare Medicaid Momentum (37:05) - Epstein Files AI Law (43:27) - Biolabs Base Rates Debate (47:27) - Business Model And AI Math Finale – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

Machine God: Hsu, Greer, Huang – #120

1 hr 14 min

Machine God is a feature-length AI documentary film, created by Steve Hsu, John Greer, and Lei Huang. This episode discusses the film's creation and content. Chapter Markers: (00:00) - Meet the Filmmakers (02:06) - Berkeley AI Boomtown Origins (19:23) - Techno Capital and the Pause Plea (38:55) - Why Slow Down AI (41:40) - Recursive Self Improvement (46:01) - Gradual Disempowerment (51:48) - Film Release and Closing –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

How to Build a Research Institute: Thomas Fink of the London Institute for Mathematical Sciences – #119

1 hr 0 min

Dr. Thomas Fink is an Anglo-American physicist, author, and entrepreneur who serves as the founding Director of the London Institute for Mathematical Sciences (LIMS). He studied physics at Caltech, where he won the Fisher Prize, and earned his PhD at Cambridge University. His research focuses on statistical physics, combinatorics, and evolvable systems, using these tools to gain insights into physical and biological systems. In 2011, Dr. Fink founded LIMS, the UK's first independent research centre for theoretical physics and mathematics. Located in the historic Royal Institution in Mayfair, LIMS operates like a university research department but with no teaching or administrative duties, allowing its researchers to focus entirely on full-time, curiosity-driven discovery. London Institute for Mathematical Sciences (LIMS): https://lims.ac.uk/ Dr. Thomas Fink's Profile at LIMS: https://lims.ac.uk/thomas-fink/ Chapter Markers: (00:00) - Thomas Fink: Caltech, Cambridge, CNRS Paris (07:27) - Rethinking Academia (13:05) - Building LIMS (31:18) - Saving Basic Science (33:46) - Endowments Versus Governments (40:28) - AI Reshaping Research Culture (52:17) - Closing Thoughts – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its custom...

Venture Capital and Technology in China with Bohan Lou – #118

1 hr 5 min

Bohan Lou is a partner at Chemistry Ventures, based in SF.https://x.com/loubohan Bohan's report on the venture ecosystem in China: https://x.com/loubohan/status/2082143914924851449 Chapter Markers: (01:42) - Venture Capital in China; Bohan’s Shanghai Roots (11:15) - Chemistry Fund and China Investing (20:04) - China Trip and Venture Reality Check (32:18) - Pressure Cooker: Founder Exits and Financial Liability (33:50) - Variation in Founder-Friendly investment environment (46:52) - AI Models and Open Source (58:56) - Big Picture and Wrap Up –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

Iran, AI, and the Third World War (Crossover with Seeking Truth From Facts Podcast) – #117

52 min

This is a crossover episode with Alf Beckinsale, an Oxford University student who hosts the Seeking Truth From Facts podcast. The main topics are the US-Iran conflict, geopolitics, and US-China AI competition. Chapter Markers: (00:00) - Introduction (02:33) - No Off Ramp in Gulf (04:11) - Missile Stockpile Crisis (06:46) - Oil Shock and Reserves (14:07) - Israel Stays Out (29:34) - China Frontier AI Surge (43:25) - World War and Nukes – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

State of AI, Summer 2026 – #116

51 min

Steve discusses the state of AI in summer 2026. Topics covered include: AI in math and theoretical physics, Recursive Self-Improvement, Agent swarms and tokenomics, IPOs and US-China competition, documentary film Machine God. Machine God trailer: https://www.youtube.com/watch?v=5RSv3wmDIpY Theoretical Physics with Generative AI: https://stevehsu.substack.com/p/theoretical-physics-with-generative Chapter Markers: (00:00) - State of AI, Summer 2026 (02:39) - AI in Math Physics (13:54) - Recursive Self-Improvement (21:08) - DeepSeek Hyperconnections (29:42) - Agent Swarms and Tokenomics (43:26) - Machine God Documentary – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is...

Beff Jezos and Effective Accelerationism: Machine God of Loving Grace – #115

1 hr 40 min

Beff Jezos (Guillaume Verdon) is a Canadian physicist, quantum computing researcher, and tech entrepreneur. He is best known as the founder of the Effective Accelerationism (e/acc) movement. This interview was recorded in collaboration with John Greer and Lei Huang for the documentary film Machine God. John Greer: https://www.johncgreer.com/ Chapter Markers: (00:00) - Meet Beff Jezos (01:56) - Hyperstition vs AI Doom (21:29) - Accelerate or Die (37:51) - Scaling Intelligence Upside (40:26) - Doomers Power Centralization (47:17) - EAC Physics Framework (01:10:10) - Debating Doom Narratives (01:16:13) - Beff Jezos Origin Story (01:28:06) - Pause Debate and Rapid Fire – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize unders...

Razib Khan at Manifest 2026: Genetic Discoveries, AI, and Academia – #114

1 hr 20 min

This episode was recorded live at Manifest 2026. Razib Khan is a prominent writer, population geneticist, and podcaster. He is best known for his extensive deep-dives into human evolutionary history, consumer genomics, culture, and ancient DNA.  https://x.com/razibkhan https://x.com/razibkhan?lang=en Chapter Markers: (00:00) - Razib Khan at Manifest 2026: Genetic Discoveries, AI, and Academia (01:18) - Manifest Q&A Kickoff (02:43) - Yamnaya: Ancient DNA Mysteries (15:01) - Yamnaya: Y Chromosome Conquests (22:10) - Embryo Screening and AI (42:15) - Conformity and Tenure (46:34) - Academia: Reforms (53:55) - Academia: Ideological Capture and Funding (58:19) - Controversies and Closing Q&A – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary...

Letter from Beijing 2: Tsinghua University – #113

1 hr 21 min

This special episode was recorded at Tsinghua University in Beijing, generally regarded as the top university in China. Our guests are 3 Americans studying and working at Tsinghua: Gabriel (undergrad), Justin (PhD student in AI), and Alex (Professor in AI research). Topics discussed include: Tsinghua University and elite human capital, AI in China, US-China competition, and the flow of human capital between the US and China Han Feizi, columnist at Asia Times and the guest from the previous "Letter from Beijing" episode, is also in the room. Letter from Beijing with Han Feizi: https://www.manifold1.com/episodes/letter-from-beijing-with-han-feizi-72 Chapter Markers: (00:00) - Welcome to Tsinghua University (02:47) - Gabriel’s Undergrad Journey (12:35) - Justin’s PhD (25:10) - Professor Alex on AI and Rankings (42:51) - Second Chances and Status Signals (46:48) - China’s Exam Ladder Explained (50:20) - Infrastructure and Tech Competition (01:17:18) - Semiconductors, EUV, and Wrap Up – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extr...

AI Billionaire on Existential Risk: Jaan Tallinn – #112

1 hr 40 min

Jaan Tallinn is a tech billionaire and founding engineer of Skype who leverages his wealth to mitigate existential risks from artificial general intelligence (AGI). He co-founded the Future of Life Institute and the Centre for the Study of Existential Risk, while making early foundational investments in frontier AI labs like DeepMind andAnthropic. Chapter Markers: 00:00 Assessing Current AI Risk Levels03:28 Inside Self-Sustaining AI Scenarios09:10 The Global AI Race Dynamics42:25 Explaining the Techno-Capital Flywheel45:34 Insider Origins of AI Safety56:06 Race Politics and Public Fear01:23:12 Pop Culture, Movies, and Fame01:30:15 Big Questions for Humanity's Future – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understand...

Embryo Selection and Frontier Genomics with Dr. Alex Young – #111

1 hr 30 min

Dr. Alex Young, a statistical geneticist and assistant professor in the Human Genetics department at UCLA, joins Steve Hsu to discuss the cutting edge of genomic prediction. They cover his research on polygenic embryo screening in IVF (including the ImputePGTA method), family-based DNA analysis, missing heritability, and the implications of polygenic scores for traits like education and disease. Alex also discusses his recent battles with cancer. https://x.com/AlexTISYoung Chapter Markers: (00:00) - Alex Young Bio (06:36) - Biobank Era Genetics (10:49) - Missing Heritability Debate (27:18) - Embryo Selection Controversy (50:32) - Embryo Selection Backlash (53:42) - Mexico City Admixture Study (01:00:13) - Censorship Via Data Access Control (01:05:02) - Battle With Cancer and Circulating Tumor DNA (ctDNA) – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned mode...

Iran War is the First Missile War (crossover with Seeking Truth From Facts podcast) – #110

49 min

Steve and Alf discuss the Iran War, emphasizing what it reveals about modern missile and anti-missile technology, drones, and the implications for a US-China conflict in the Western Pacific. Links:https://seekingtruthfromfacts.substack.com/ Chapter Markers: (00:00) - Missile War Reality Check (01:49) - How the War Started (04:46) - Iran Outperforms Expectations (06:22) - Why Missile Defense Fails (14:25) - Ceasefire and Hormuz Brinkmanship (19:52) - Nukes and the JCPOA Fallout (33:44) - US Politics and Israel Lobby Aftershocks – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

Dreamers and Doomers: Our AI future, with Richard Ngo – #109

1 hr 51 min

Richard Ngo is an independent AI researcher and philosopher known for his work on AGI safety and alignment. He recently resigned from OpenAI, where he was a member of the Governance team focused on forecasting the capabilities and risks of advanced AI systems. His debut fiction collection is titled "The Gentle Romance: Stories of AI and Humanity", published in December 2025. The book features 22 science fiction stories that explore the psychological and sociological impacts of advanced artificial intelligence. On X: @RichardMCNgo (00:00) - Richard Ngo Origins (03:48) - DeepMind vs LLMs (09:24) - OpenAI Futurist and AGI Risk (39:17) - Machine God Tail Risk (45:20) - Weird Futures and Normies (51:28) - Alignment Research and Academia (01:16:25) - Doomers vs Skeptics (01:23:57) - Labs Governance Futures (01:39:37) - Doom Scenarios Society – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build eva...

China, Acceleration, and Nick Land - with Matt Southey – #108

1 hr 3 min

Matt Southey is an editor for an AI safety organization. He wrote his PhD dissertation on the philosophy of Nick Land. Matt's "A Brief History of Accelerationism" can be found here, and he recommends the second chapter of Crypto-Current as a good introduction to Land's usage of Kant. He and Steve discuss Accelerationism, AI, and Steve's recent meeting with Land in Shanghai. Chapter Markers: (00:00) - Introduction (02:07) - China Trip: Shenzhen, Beijing, Shanghai (03:16) - Tsinghua University: Talent (09:02) - Robotics and AI research (24:01) - Shanghai and Nick Land (35:46) - Land’s Esotericism (37:19) - Accelerationism and Orthogonality (43:01) - Simulation Metaphysics and Physics (54:36) - Dark Enlightenment and Inevitable Complexity – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and origi...

Shenzhen is the Technology Capital of the World, with Taylor Ogan – #107

1 hr 11 min

Recorded live in Shenzhen with Taylor Ogan, the founder and CEO of Snowbull Capital, which invests in Chinese technology companies. Taylor on X: https://x.com/TaylorOgan Previous episodes with Taylor: https://youtu.be/iehHON07UHI?si=h2c3po5AX9Z9ANaK  https://youtu.be/fmjR3me5s_Q?si=sPsMFOdKebEOZXQr (00:00) - Shenzhen is the Technology Capital of the World, with Taylor Ogan (00:53) - Meeting in Shenzhen (02:40) - Greater Bay Area Explained (06:36) - Shenzhen Boom Stories (18:26) - China Tech Reality Check (36:49) - China Tech Leapfrogging (37:52) - Agentic AI on Phones (41:27) - Jobs Wealth and Governance (53:03) - Huawei Ownership and US Pushback –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership...

AI DOOM: Jesse Hoogland of Timaeus

1 hr 42 min

This is the second episode of our series based on interviews for the documentary film, Dreamers and Doomers, about the SF Bay Area in the last days before AGI.  Steve interviews Jesse Hoogland, co-founder and executive director of Timaeus, an AI safety research org working on applications of Singular Learning Theory (SLT) for AI safety. SLT establishes a connection between the geometry of the loss landscape and internal structure in models. This connection is used to develop scalable, rigorous tools for evaluating, interpreting, and aligning neural networks. Jesse is one of the leading young minds in the new generation of AI safety researchers. https://www.jessehoogland.com/ (00:00) - Jesse interview at FAR Labs, Berkeley (00:54) - Introduction (01:50) - From Physics to AI Safety (08:36) - AI Is Dangerous (26:08) - Funding, P(Doom), and Futures (56:21) - Trauma and Safety Vibes (01:00:39) - Asymptotic Guarantees Debate (01:03:54) - Mapping the Safety Tribes (01:26:09) - Timelines, AI Pause, and Failure Modes – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work...

Dreamers and Doomers: Jeremy Nixon at AGI House – #105

2 hr 14 min

Jeremy Nixon is a prominent AI researcher, entrepreneur, and the co-founder of AGI House, a leading "hacker house" community for artificial intelligence developers in Silicon Valley. He studied Applied Math, Computer Science, and Economics at Harvard and was previously a researcher at Google Brain. This footage was shot for a documentary project, "Dreamers and Doomers," about the SF Bay Area and the dawn of AGI. (00:00) - Dreamers and Doomers: Jeremy Nixon at AGI House – #105 (01:47) - Introduction and Welcome (05:56) - Jeremy Nixon's biography (08:48) - AGI House and collectives (43:59) - AI and Scientific Research (45:52) - Existential Risks and Doom (54:14) - AI and Human Progress (01:26:42) - Job Automation and Society (01:31:35) - Future of AI and Technology – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker:...

Industrial Maximalism and Its Discontents: Dan Wang on US-China Competition – # 104

1 hr 24 min

Links: Breakneck: China's Quest to Engineer the Future https://www.amazon.com/Breakneck-Chinas-Quest-Engineer-Future/dp/1324106034 Dan's 2025 annual letter https://danwang.co/2025-letter/ Related episodes: Jian Lian on Industrial Maximalism, Manifold Episode #99 https://www.manifold1.com/episodes/jian-lian-on-chinas-industrial-policy-and-global-strategy-99 (00:00) - Introduction and Welcome (02:14) - Breakneck - Dan's huge book (05:00) - China's Technological and Political Landscape (21:07) - Industrial Maximalism and its Discontents (47:59) - Chinese Researchers in Silicon Valley and Tsinghua (51:09) - Excerpts from Dan's 2025 annual letter (52:56) - China's Market Competition and Innovation (56:34) - AI, Automation, and Future Risks – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and orig...

Geopolitics 2026, crossover with Seeking Truth From Facts podcast – #103

47 min

Steve and Alf discuss geopolitical events of 2025 and what they expect in 2026. Links: Manifold episode with Han Feizi, Letter From Beijing https://www.manifold1.com/episodes/letter-from-beijing-with-han-feizi-72 Previous crossover episodes: Weeks Where Decades Happen https://www.manifold1.com/episodes/seeking-truth-from-facts-weeks-where-decades-happen AI, China, Tariffs, Geopolitics https://www.manifold1.com/episodes/seeking-truth-from-facts-ai-china-tariffs-geopolitics-84 (00:00) - Geopolitics 2026, crossover with Seeking Truth From Facts podcast – #103 (02:10) - US-China Economic Tensions (05:45) - Technology and Strategic Shifts (08:48) - Trump's Geopolitical Strategy (17:43) - Middle East Developments (28:41) - US-China Competition and Taiwan (33:44) - Venezuela and International Law – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors ...

Polygenics and Machine SuperIntelligence; Billionaires, Philo-semitism, and Chosen Embryos – #102

1 hr 0 min

This is a two-part episode. The first ~30m covers the most important 2025 breakthroughs in polygenic embryo screening, while the second 30m focuses specifically on AI capabilities at the frontier of human knowledge. Both segments make predictions for 2026 and beyond. Links: Chinese billionaires, Philo-semitism, and the Chosen embryos: https://x.com/hsu_steve/status/2000206116823675078 My talk from Reproductive Frontiers 2025 in Berkeley: https://www.youtube.com/watch?v=n64rrRPtCa8 Previous episodes on frontier AI capabilities in math and theoretical physics https://www.manifold1.com/episodes/theoretical-physics-with-generative-ai-101 https://www.manifold1.com/episodes/ais-win-math-olympiad-gold-prof-lin-yang-ucla-97 Chapter Markers: (00:00) - Introduction (02:22) - Advancements in Polygenic Prediction of Human Traits (03:20) - Polygenic Risk Scores in Healthcare (08:15) - Embryo Selection and IVF (20:37) - Public Perceptions: billionaires and FOMO (31:40) - AI advances in 2025: High end capabilities and use of AI at the frontier of human knowledge (55:33) - Conclusion and predictions for 2026 – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in...

Theoretical Physics With Generative AI – #101

1 hr 12 min

All but the last 20 minutes of this episode should be comprehensible to non-physicists. Steve explains where frontier AI models are in understanding frontier theoretical physics. The best analogy is to a “brilliant but unreliable genius colleague”! He describes a specific example: the use of AI in recent research in quantum field theory (Tomonaga-Schwinger integrability conditions applied to state-dependent modifications of quantum mechanics), work now accepted for publication in Physics Letters B after peer review. Remarkably, the main idea in the paper originated de novo from GPT-5. Links: X discussion - https://x.com/hsu_steve/status/1996034522308026435Companion paper: Theoretical Physics With Generative AI -  https://drive.google.com/file/d/16sxJuwsHoi-fvTFbri9Bu8B9bqA6lr1H/viewPhysics paper - https://arxiv.org/abs/2511.15935 | https://www.sciencedirect.com/science/article/pii/S0370269325008111Related discussion of AI and theoretical physics with Prof. Nirmalya Kajuri (IIT) and Prof. Jonathan Oppenheim (UCL) - https://youtu.be/BRuDd3l0e3kRelated video: AIs Win Math Olympiad Gold: Prof. Lin Yang (UCLA) – Manifold #97 - https://youtu.be/8JeRCqNg7RcChapter markers: (00:00) - Intro: AI discussion with specialized physics at the end (03:40) - The current AI landscape for science: frontier models, Co-Scientist, and recent math breakthroughs (11:01) - Why models help and why they fail: errors, deep confabulation, and the research risk (15:54) - The Generator–Verifier workflow: how chaining model inference suppresses mistakes (23:30) - Project origin: testing models on Hsu’s older nonlinear QM/QFT work (30:35) - The “GPT-5 moment”: Tomonaga–Schwinger angle appears and produces the key equation (40:35) - Wild goose chases & a practical heuristic: axiomatic QFT detour; Generator-Verifier convergence (51:44) - Referee-driven test case: Kaplan–Rajendran model, past-lightcone geometry, and verification (55:55) - Tooling & outlook: automation prototype, chaining into “superm...

Jeffrey Epstein, Israel, and Elite Power, with Murtaza Hussain – #100

1 hr 3 min

Murtaza Hussain is a reporter for Drop Site News, which has broken important stories based on recently obtained Epstein emails. Hussain reports that Epstein had an “extensive relationship with Israeli intelligence, U.S. intelligence and the intelligence agencies of other countries, as well... He was a dealmaker and a fixer at a very, very elite level.” Links: Drop Site News series on Epstein and Israel https://www.dropsitenews.com/s/epstein-and-israel Former Israeli spy Ari Ben Menashe on Jeffrey Epstein https://x.com/hsu_steve/status/1994046737040712144 (01:08) - Introduction (02:20) - The Mission of Drop Site News (06:00) - Epstein Emails (15:28) - Epstein connections and elite power (35:48) - Epstein and intel agencies (39:54) - Ari Ben Menashe and the Iran Contra Affair (42:21) - Media Censorship and Political Implications (47:33) - The Future of Epstein Investigations – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example: ...

Jian Lian on China's Industrial Policy and Global Strategy – #99

1 hr 12 min

Jian Lian is an expert on China's political economy, industrial development, and technological development. He graduated from Peking University with a bachelor's and master's degree in economics. Starting out as an industry analyst at a Chinese investment bank, he participated in the "Made in China 2025" initiative as a Chinese venture capitalist, working for a state-owned fund. He is the author of "The Truth About Capital" 资本的真相 (2016), which contains major predictions about technology, economy, and society in China, most of which have since come true. Jian and Steve discuss the origins of the industrial party movement (discussed in an earlier episode with Kyle Chan), which culminated in the "industrial maximalism" view of development adopted by the PRC government. They also discuss the development of supply chains in China, and the role that US sanctions had in accelerating the Chinese semiconductor industry. Kyle Chan episode: https://www.manifold1.com/episodes/kyle-chan-on-the-future-of-us-china-competition-94 Chinese industrial maximalism:  https://www.high-capacity.com/p/chinese-industrial-maximalism (00:00) - Introduction (00:49) - Jian Gaokao score was 23rd in all of Fujian = Econ at Beida, not Genomics! (05:21) - China's Industrial Policy and Innovation (24:19) - Domestic supply chain strategy; How Huawei became a national champion due to US sanctions (34:13) - Venture Capital in China (36:13) - Hard Tech Investments (37:40) - Regulations of Tech Giants (44:28) - Future of China Technological Development – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at C...

Scott Horton on the Russia Hoax and Ukraine War – #98

1 hr 25 min

Scott Horton is the author of Provoked: How Washington Started the New Cold War with Russia and the Catastrophe in Ukraine. Horton is a libertarian and anti-war activist. He and Steve discuss the Russia Hoax and its connection to American foreign policy, in light of new evidence that has emerged since the first Trump term. Scott’s book: https://www.amazon.com/Provoked-Washington-Started-Catastrophe-Ukraine/dp/1733647376X handle: @scotthortonshow (00:00) - Scott Horton on the Russia Hoax and Ukraine War – #98 (01:49) - Scott Horton's Political Journey (04:55) - The State of Public Awareness and Media (11:42) - Russiagate and the Indictment of James Comey (43:13) - Perjury and Obstruction Charges: The Virginia Trial Dilemma (43:51) - The Durham Investigation: Unveiling Corruption (46:28) - Post-Durham Report Revelations (59:04) - Ukraine Conflict: Provoked or Unprovoked? – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU.Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research...

AIs Win Math Olympiad Gold: Prof. Lin Yang (UCLA) – #97

50 min

Lin Yang is a professor of computer science at UCLA. Recently, he and his collaborator built an AI pipeline using commercial models such as Gemini, ChatGPT, and Grok that performed at the gold medal level on International Mathematics Olympiad problems. Steve and Lin discuss this research, which relies on "verifier-refiner" LLM instances and large token budgets to reliably solve difficult problems. They discuss how these methods can be used to advance AI for scientific research, legal analysis, and complex document processing. https://github.com/lyang36/IMO25/blob/main/IMO25.pdf https://x.com/hsu_steve/status/1948189075707469942 Chapter markers: (00:00) - AIs Win Math Olympiad Gold: Prof. Lin Yang (UCLA) – #97 (00:57) - Prof. Lin Yang, UCLA (04:27) - Journey from Physics to Computer Science: 2 PhDs (11:15) - Transition to AI from Theoretical CS (13:16) - AI Pipeline Math Olympiad: Gold Medal! (28:23) - Probability Amplification (29:00) - Applications in Industry and Legal Analysis (29:58) - Challenges in Model Reasoning and Verification (33:23) - Future of AI in Scientific Research and AGI Speculations – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU.Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthroug...

The Global AI Race: Z.ai and the View from Beijing — #96

1 hr 6 min

Zixuan Li is Director of Product and genAI Strategy at Z.ai. He was educated at Renmin and Tsinghua University in China, and at MIT and Carnegie Mellon. Z.ai has released frontier open source LLMs but is largely unknown in the West except among AI experts. Steve and Zixuan discuss the AI race from the perspective of a startup in Beijing. https://chat.z.ai/Follow Z.AI on X: @Zai_org Chapter markers: (00:00) - Introduction and Guest Background (05:14) - Z.ai's Evolution and Challenges (10:37) - AI Model Comparison and Industry Insights (34:04) - Pragmatic Views on AGI in China (35:51) - Specialized Models and Scientific Contributions (39:02) - AI Chips and Model Training in PRC (50:54) - Open Source AI and Future Predictions – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU.Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles th...

Seeking Truth From Facts: Weeks Where Decades Happen — #95

48 min

This episode is a co-release with the Seeking Truth From Facts podcast: https://substack.com/@seekingtruthfromfacts The theme of this episode derives from Lenin: “There are decades where nothing happens; and there are weeks when decades happen.” ― Vladimir Ilyich Lenin   Steve and Alf discuss: (00:00) - Introduction (01:32) - China Victory Day Parade and new military technology (12:27) - The SCO summit and its implications (20:24) - Modi's presence and the prospect of a Sino-Indian rapprochement (25:00) - Trump's South Asian blunder? (32:14) - The Alaska Summit and the chances of peace (40:01) - Israel's loss of popular support on both the left and the right (46:12) - Bipolarity or multipolarity? – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $3...

Kyle Chan on the Future of US-China Competition — #94

1 hr 10 min

Kyle Chan is a Postdoctoral Research Associate and Lecturer in Sociology at Princeton University. His research focuses on industrial policy, clean technology, and infrastructure with a regional focus on China and India. He is currently working on a book on Chinese industrial policy that aims to explain how China came to dominate certain industries today that had originally been led by the US, Japan, and other industrialized nations. These industries include electric vehicles, solar, high-speed rail, and consumer electronics. The book will describe the wide range of industrial policy tools used in China and their ongoing efforts in other industries, such as semiconductors and biotechnology. Kyle Chan writes a popular newsletter called High Capacity on industrial policy, clean technology, and infrastructure, particularly in China and India. Personal website: https://www.kyleichan.com/ NYT op-ed: https://www.nytimes.com/2025/05/19/opinion/china-us-trade-tariffs.html Lu Feng interview: https://www.high-capacity.com/p/chinese-industrial-maximalism Chapter Markers: (00:00) - Introduction (00:50) - Kyle's Background and Research Interests (05:51) - China vs. India: A Comparative Study of Railway Development (12:38) - The Broader Implications of Industrial Policy (37:48) - Introduction to Industrial Maximalism (38:54) - China's Manufacturing Strategy (41:33) - US-China Technological Competition (59:45) - Global Collaboration and Future Outlook Music used with permission from Blade Runner Blues Livestream improvisation by State Azure. – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educate...

Joleen Liang: 40M+ kids educated by adaptive AI — #93

59 min

Dr. Joleen Liang is Co-founder of Squirrel AI, which pioneered adaptive learning at scale, first in China and now in the US. By 2021 its technology had served over 60,000 public schools in 1,200 cities across Asia. Squirrel AI has implemented large knowledge graphs mapping out the main concepts in the K-12 math, science, and language curriculum. The Squirrel learning tablet actively observes student behavior (including eye-tracking during video lessons) and adapts its presentation and testing to individual learning patterns. Chapter markers: (00:00) - Joleen Liang: Co-Founder of Squirrel AI (02:14) - Squirrel AI: Beginnings and scale (14:44) - AI vs Human Teachers (33:51) - Learning environment: tablet, headphones, human supervisors/analysts (51:11) - Challenges and Opportunities in the US Market Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.–Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For e...

Max Dama on HFT: Millisecond Algos and Bid/Ask Dynamics — #92

54 min

Max Dama is the co-chairman of Headlands Technologies LLC, a global quantitative proprietary trading firm headquartered in Chicago, with offices in New York, Austin, London, Amsterdam and Singapore. He earned a B.A. in Mathematics, Statistics, Computer Science, and Business from the University of California, Berkeley. A generation of quants know Max through his notes on automated trading and on interview brain teasers. https://work-in-progress.notion.site/Max-Dama-s-Brainteasers-Study-Guide-WIP-9eb1f4b692f241d894462ddf1ab34617http://isomorphisms.sdf.org/maxdama.pdf Steve and Max discuss: (00:00) - Introduction (01:18) - Max Dama's Early Life and Education (02:19) - Journey into Trading and Career Development (06:56) - The High-Frequency Trading Industry (26:42) - Academic Foundations for Trading (27:50) - Computer Science in Trading (28:57) - Insights into the Trading Industry (35:49) - AI and the future of HFT Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.–Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Comp...

Andrew Song: Global Cooling with Sulfur Dioxide in the Stratosphere — #91

1 hr 4 min

Andrew Song is a co-founder of Make Sunsets, a company focused on addressing climate change through solar geoengineering. The company launches balloons filled with sulfur dioxide (SO2) into the stratosphere with the aim of reflecting sunlight to cool the Earth. https://makesunsets.com/ Previous Manifold episodes on climate: https://www.manifold1.com/episodes/casey-handmer-terraform-industries-and-a-carbon-neutral-future-57https://www.manifold1.com/episodes/tim-palmer-status-and-future-of-climate-modeling-16https://www.manifold1.com/episodes/klaus-lackner-on-carbon-capture-climate-change-and-physics-40Steve and Andrew discuss: (00:00) - Introduction (01:35) - Andrew's Background and Swimming Career (06:37) - Journey into Startups and Y Combinator Experience (11:30) - Make Sunsets: Concept and Science (32:53) - Exploring Supersonic and Balloon-Based Solutions (33:45) - Environmental Concerns and Biodegradable Solutions (36:13) - Business Model and Cooling Credits (39:26) - Future Prospects and Climate Modeling Challenges Music used with permission from Blade Runner Blues Livestream improvisation by State Azure. – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the bre...

Manifold Discord Channel: Live Q&A with Steve — #90

54 min

Manifold has its own Discord channel!  https://discord.gg/dvcHS6NX The purpose of the channel is to create a community of listeners with shared interests. It developed from a series of in-person meetups with Steve in cities like SF, NYC, Singapore, Beijing, Shanghai. Chapter markers: (00:00) - Manifold Discord Channel, Live Q&A (02:36) - Genomics and Predictive Genetics (09:28) - Trump Administration, Epstein, and Political Commentary (29:42) - Missile Defense Systems: Historical Challenges and Modern Realities (36:48) - Failures and Cover-Ups in Missile Defense (45:23) - Developing Intellectual Taste and Productivity Tips Links related to Q&A:Best genomic predictor for cognitive ability: https://x.com/hsu_steve/status/1936401098345980207Ted Postol on missile defense: https://www.manifold1.com/episodes/theodore-a-postol-nuclear-weapons-missile-technology-and-u-s-diplomacy-12Sputnik moment: https://x.com/hsu_steve/status/1873541234125316367China-US comparisons: https://www.manifold1.com/episodes/letter-from-beijing-with-han-feizi-72https://www.manifold1.com/episodes/letter-from-shanghai-reflections-on-china-in-2024-73https://x.com/hsu_steve/status/1934216476560388250 Music used with permission from Blade Runner Blues Livestream improvisation by State Azure. – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize -...

Omar Shams: AI Founder and Google AI Agent Lead — #89

1 hr 5 min

Shams was trained in theoretical physics before becoming an AI engineer at DeepMind and founding the company Mutable, which was acquired by Google. He is now lead engineer for Google's software agent group. Steve and Omar discuss: (00:00) - Introduction (01:18) - Journey from Physics to AI (10:51) - Elon Tried to Buy DeepMind (16:52) - Building Mutable and Auto Wiki as Context for LLMs (33:39) - The Value of AI Talent and Meta's AI Hiring Spree (42:58) - AI and The Workforce (58:02) - The Intersection of Physics and AI Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.– Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY G...

Patrick McGee: Apple In China — #88

59 min

Patrick McGee is a longtime FT business reporter with extensive experience reporting on China. He is the author of the highly acclaimed Apple in China: the capture of the world's greatest company. Steve and Patrick discuss the history of Apple and its impact on technology development in China.   “The best book about Apple ever written, one of the best books about China ever written, and one of the best books about tech, period.” —Ben Thompson, Stratechery.   Apple in China on Amazon: https://www.amazon.com/Apple-China-Capture-Greatest-Company/dp/1668053373 (00:00) - Introduction to Patrick McGee and his Book (03:05) - The Apple-Foxconn Partnership (07:07) - China's Industrial Transformation and Apple's Role (32:48) - Automation Challenges in Apple's Production (34:50) - Chinese Innovation and Huawei's Rise (36:15) - The Impact of US-China Trade Tensions (38:08) - Apple's Internal Struggles and Future Outlook (48:56) - Hidden gems in the book Music used with permission from Blade Runner Blues Livestream improvisation by State Azure. – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring! ...

GODZILLA DOWN! India-Pakistan Clash and Chinese Military Technology with TP Huang — #87

1 hr 2 min

Steve and TP discuss the implications of the recent air battle between India and Pakistan, which involved over 100 fighter jets and took place entirely beyond visual range (BVR). What is sensor fusion, and have the Pakistanis achieved it with Chinese technology? Does the PL-15 outrange and outperform Western air-to-air missiles? What are the implications for US-China military competition? Read TP Huang on X:  https://x.com/tphuang   (00:00) - GODZILLA IS DOWN! India-Pakistan Clash and Chinese Military Technology with TP Huang — #87 (00:32) - Introduction to the India-Pakistan Conflict (02:15) - Details of the Air Battle (04:40) - Expert Analysis by TP Huang (08:34) - Analysis of Air Battle Tactics and Technology (12:40) - Role of Chinese Technology (16:13) - Implications for Future Warfare (25:23) - Indian and Pakistani Military Strategies (34:34) - Unexpected Aggression: India's Miscalculation (36:52) - Pakistan's Strategic Restraint (39:19) - The Rafale Controversy: A Deep Dive (43:08) - Electronic Warfare: Myths vs. Reality (52:31) - Future of Indian Air Force: Tough Choices Ahead Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.– Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its cu...

Robots, Small Models, and RL with DeepSeek Alumnus Zihan Wang — #86

1 hr 7 min

Zihan Wang is an AI researcher at Northwestern University, where he works on vision-language models, robotics, and reinforcement learning. Previously, he interned at DeepSeek, contributing to projects like DeepSeek-V2. Zihan's homepage:  https://zihanwang314.github.io/ (00:00) - Introduction (01:13) - Zihan's Background, CS and AI Research in China (11:09) - DeepSeek; Human capital flow from PRC to US (16:07) - DeepSeek, Open Source and AI Research (31:52) - Model Size and Performance Constraints (33:01) - Data Bottleneck in Pre-trained Models (34:12) - Transformer Architecture and Scaling Laws (36:30) - Efficiency in Model Training (47:44) - Chain of Experts Architecture (01:01:06) - Future of AI and Robotics Music used with permission from Blade Runner Blues Livestream improvisation by State Azure. – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model beha...

Dan Collins: Tariffs and the Future of US Manufacturing — #85

1 hr 18 min

Dan Collins is Founder of Tyrell Chemical. He studied at Tsinghua University and spent 20 years working for companies like General Motors in China, helping to localize automotive manufacturing. Dan and Steve discuss tariffs, deindustrialization in America, the Go-Go days of rapid economic growth in PRC, and the future of the US-China relationship. Follow Dan on X: https://x.com/DanCollins2011 (00:00) - Introduction (01:25) - Dan's Early Life and Education in Michigan (02:30) - Experiences in China, Tsinghua University (05:42) - China's Educational and Economic Transformation (14:39) - US-China Trade Relations and Joint Ventures (41:48) - China's Auto Market (42:38) - Weaponization of Customs and Nationalism (43:20) - Impact of Tariffs on US Manufacturing (44:28) - Chaos in Global Trade and Supply Chains (49:34) - The Golden Screw Theory and Manufacturing Dependence (51:50) - Strategies for Reindustrializing the US Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.– Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu ...

Seeking Truth From Facts: AI, China, Tariffs, Geopolitics — #84

45 min

This episode is a co-release with the podcast Seeking Truth From Facts: https://seekingtruthfromfacts.substack.com/ (00:00) - Introduction (01:11) - China AI (02:30) - DeepSeek (04:21) - Redirecting Human Capital from finance (08:42) - US Policy and Financial Incentives (12:54) - China Meritocracy (24:24) - Trump's Tariffs and China (37:12) - European Defense and Security (41:49) - US-China-Europe Relations Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.–Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

Incels, Evo Psych, and Modern Literature with ARX-Han — #83

1 hr 25 min

Steve speaks with ARX-Han, an anonymous writer, about his book "Incel." (00:00) - Introduction (02:09) - Discussing the Novel 'Incel' (06:08) - Character Analysis and Literary Influences (13:32) - Themes of Evolutionary Psychology and Nihilism (18:38) - Historical Context and Modern Inceldom (26:18) - Impact of Dating Apps on Modern Relationships (32:47) - Representation and Character Dynamics (40:21) - Literary Comparisons and Philosophical Depth (45:38) - Philosophical Underpinnings of Meaning (48:14) - The Hard Problem of Consciousness (50:38) - Free Will and Determinism (52:53) - Darwinian Nihilism and Nick Land (58:17) - Historical Perspectives on East Asian Civilization (01:03:11) - The State of Literary Fiction (01:16:45) - AI and Literature (01:19:44) - AI and Human Meaning Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.– Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Resea...

Callum Williams: Economics, AI, and Technological Progress — #82

1 hr 46 min

Callum Williams is a senior economics writer for The Economist. He was educated at Oxford, Harvard, and Cambridge, and is the author of The Classical School: The Birth of Economics in 20 Enlightened Lives. (00:00) - Introduction (02:07) - US-Russia Relations (03:18) - Trump and US Foreign Policy (05:30) - Sanctions and Their Impact on Russia (09:28) - Economic Resilience and Sanctions Evasion (14:14) - Historical Context and Predictions (29:37) - US Wealth Inequality (40:37) - Debating Wealth Inequality and Welfare States (42:35) - Homelessness and Government Intervention (45:18) - Employment Rates and Economic Behavior (50:12) - San Francisco's Homelessness Crisis (53:46) - US vs. Europe: Economic Divergence (01:06:06) - Cultural Differences in Economic Growth (01:10:48) - AI and Job Market Transformation (01:13:50) - Challenges in AI Adoption (01:15:16) - Consumer vs. Business Tech Adoption (01:15:56) - Slow AI Integration in Businesses (01:17:34) - AI in Customer Service (01:23:48) - Resistance to AI (01:26:36) - AI and Productivity (01:37:35) - Debates on Technological Progress Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.– Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities...

Misha Laskin, Reflection.ai — From Physics to SuperIntelligence

53 min

Misha Laskin is CEO of Reflection.ai. He was trained in theoretical physics at Yale and Chicago before becoming an AI scientist. He made important contributions in Reinforcement Learning as a researcher at Berkeley, Google DeepMind, and on the Google Gemini project. https://x.com/MishaLaskin Steve and Misha discuss: (00:00) - Introduction (00:47) - Misha's Early Life and Education (03:50) - Transition from Physics to AI (05:47) - First Startup Experience (07:19) - Discovering Deep Learning (08:06) - Academic Postdoc at Berkeley (14:31) - Joining Google DeepMind (16:36) - Reinforcement Learning and Language Models (26:42) - Challenges and Future of AI (48:30) - Unique Perspective from Physics Music used with permission from Blade Runner Blues Livestream improvisation by State Azure. – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K sala...

Taylor Ogan, Snow Bull Capital: China's tech frontier, the view from Shenzhen, Part 2

1 hr 25 min

Taylor Ogan is Chief Executive Officer of Snow Bull Capital, based in Shenzhen, China. His firm invests in Chinese technology companies, with a focus on areas such as clean energy, AI, and automation.   Part 1 of this discussion, from November 2023: https://www.manifold1.com/episodes/taylor-ogan-snow-bull-capital-chinas-tech-frontier-the-view-from-shenzhen-47   Steve and Taylor discuss:  (00:00) - Introduction (01:23) - Shenzhen: The Tech Hub of China (04:14) - The Rise of Huawei and Its Impact (06:59) - DeepSeek: China's AI Breakthrough (11:32) - The Role of Government in Tech Development (26:17) - Humanoid Robots: The Next Frontier (38:01) - Huawei and PLA? (40:49) - The Semiconductor Race (43:13) - Huawei's accelerated chip development (45:13) - Government's Role in Technological Advancements (46:21) - China's Domestic Tech Ecosystem (48:56) - Venture Capital and Entrepreneurship in China (51:57) - Corporate Culture and Innovation (55:48) - China's Competitive Edge in Various Industries (01:00:00) - Perceptions and Realities of Chinese Tech (01:08:37) - When will China be "investible" again for Western funds?   Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.     –  Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for trainin...

Ken Liu: Art in the Age of AI — #79

1 hr 7 min

Ken Liu (born 1976) is an American author of science fiction and fantasy. Liu has won multiple Hugo and Nebula Awards for his novel translations and original short fiction. Liu's short story "The Paper Menagerie" is the first work of fiction, of any length, to win all of the Nebula, Hugo, and World Fantasy Awards. Besides his original work, Liu's translation of Liu Cixin's Chinese language novel The Three-Body Problem (the first in the Remembrance of Earth's Past trilogy) won the 2015 Hugo Award for Best Novel, making it the first translated novel to have won the award.   He studied English Literature and Computer Science at Harvard College, and graduated from Harvard Law School.   https://kenliu.name/   Steve and Ken discuss:    00:00 Meet Ken Liu: Acclaimed Sci-Fi and Fantasy Writer 04:25 The Immigrant Experience and Cultural Perspectives 09:22 Harvard, MSFT, HLS, Litigation 15:01 The Art of Storytelling and Technology 34:03 Controversy in AI Reasoning 34:31 Technology Outstripping Science 35:22 AI and the Arts 38:30 The Future of AI in Art 42:44 AI's Role in Creative Processes 50:04 Art, Automation, and Society 57:31 Favorite Science Fiction and Fantasy 01:03:06 The Genius of Philip K. Dick Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.     –  Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this...

US-PRC Tech War: DeepSeek AI and 6th Generation Fighters — #78

2 hr 1 min

(00:00) - Introduction: AI, Miltech, and Balance of Power (00:32) - DeepSeek AI R1 model (02:36) - DeepSeek: top performance, 30x efficient compute (10:37) - DeepSeek technical innovations (15:38) - The AI Race: U.S. vs. China (34:20) - Fighter Jets and Military Technology (42:54) - Fifth to Sixth Generation Fighter Programs (46:13) - Technology of China's 6th Generation Planes (52:20) - Chinese Sixth Generation Aircraft Capabilities (01:00:50) - Strategic Implications for the U.S. and Future Developments (01:27:48) - Disabling Military Bases (01:31:17) - Implications for the U.S. and China (01:35:26) - Future Defense Strategies and Realities Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.-- Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzz...

Jim Haslam: Covid Origins and Coronavirus Genetic Engineering — #77

1 hr 55 min

Relevant links: Jim Haslam on X: https://x.com/jhas5Jim's Substack: https://jimhaslam.substack.com/Jim's book, "COVID-19: Mystery Solved," on Amazon: https://www.amazon.com/COVID-19-Mystery-Solved-leaked-Chinese-ebook/dp/B0DPVT9LWV?ref_=ast_author_cp_dpChapters: (00:00) - A quick note on my interview with Jim Haslam (03:40) - Introducing Jim Haslam, author of "COVID-19: Mystery Solved" (04:51) - The DARPA DEFUSE Grant Proposal (08:52) - Ralph Baric and Genetic Engineering of Coronaviruses (20:10) - Danielle Anderson and the Wuhan BSL-4 Lab (24:38) - The Role of EcoHealth Alliance and Peter Daszak (29:28) - The Furin Cleavage Site Controversy (36:43) - NIAID Funding and the Wuhan Connection (40:53) - Capabilities and Limitations of the Wuhan Institute of Virology, Baric's Lab (44:41) - The DEFUSE Grant and Wuhan Institute of Virology (48:22) - RaTG13 Genome and Its Implications (50:34) - Kristian Anderson's Alarming Discovery (01:00:42) - Feb. 1 Teleconference with Fauci & Baric; Feb. 3 NAS Meeting (01:19:41) - Unintentional vs. Intentional Engineering (01:21:28) - Tracing the Virus to Wuhan, Patient Zero, and the Role of Danielle Anderson (01:29:38) - Rocky Mountain Lab and Virus Processing (01:36:32) - Animal Models, Engineering Aerosol Transmission (01:42:23) - The Smoking Gun Email Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. Th...

Joscha Bach: Consciousness and AGI — #76

1 hr 21 min

Joscha Bach is a German cognitive scientist, AI researcher, and philosopher known for his work on cognitive architectures, artificial intelligence, mental representation, emotion, social modeling, multi-agent systems, and the philosophy of mind.   Links of interest: http://bach.ai/https://x.com/PlinzSteve and Joscha discuss: (00:00) - Introduction (01:26) - Growing up in the forest in East Germany (06:23) - Academia: early neural net pioneers, CS and Philosophy (10:17) - The fall of the Berlin Wall (14:57) - Commodore 64 and early programming experiences (15:29) - AGI timeline and predictions (19:35) - Scaling hypothesis, beyond Transformers, universality of information structures and world models (25:29) - Consciousness (41:11) - The ethics of brain interventions, zombies, and the Turing test (43:43) - LLMs and simulated phenomenology (46:34) - The future of consciousness research (48:44) - Cultural perspectives on suffering (52:19) - AGI and humanity's future (58:18) - Simulation hypothesis (01:03:33) - Liquid AI: Innovations and goals (01:16:02) - Philosophy of Identity: the Transporter Problem, Is there anything beyond memory records?   Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.     –  Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that build...

Adventures in Physics, Trump, and more, with the Information Theory podcast — #75

1 hr 19 min

This episode is an interview I did with the new podcast Information Theory. The host of Information Theory is an anonymous technologist trained in physics and machine learning. Information Theory Podcast on YouTube: https://www.youtube.com/@InformationTheoryPodInformation Theory Podcast on Spotify: https://open.spotify.com/show/6PbxeOYInRuH4DBXOAOq5u?si=q90fZh8PRUut5c1XG4K7Sw  (00:00) - Introduction to Information Theory podcast (01:19) - The education of a physicist (10:53) - Computational genomics (19:40) - Thinking styles and collaboration in theoretical physics (26:08) - Scientific progress and the Great Stagnation (40:39) - University research administration (45:05) - Reproducibility crisis (57:58) - Impact of basic research (01:03:16) - Critique of NIH and biomedical research (01:06:48) - Personal reflections on Trump's re-election and an inside view of the 47 transition (01:12:37) - Silicon Valley and US politics (01:15:30) - Concerns and hope for America's future Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.-- Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier mo...

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