Physionic

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The BEST Blood Pressure Lowering Exercise Just Got Better!

Nov 9, 2026 6 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:23 - Summarizing the Past2:00 - Even more Impressive!4:39 - How to Use ThisReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 387] Schneider VM, Ziegelmann PK, Pereira DM, Ferrari R. Effects of different exercise training modalities on 24-hour ambulatory blood pressure in adults with hypertension: a network meta-analysis of randomised controlled trials. Br J Sports Med. 2026;60(13):983-990. doi:10.1136/bjsports-2025-111474.[Study 1117] Swift HT, Pedlar C, Coleman DA, Buckley JP, Wiles JD. Isometric exercise training and blood pressure control: exploring the dose-response to training frequency in a randomised controlled trial. BMJ Open Sport Exerc Med. 2026;12. doi:10.1136/bmjsem-2025-003172.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

FDA approved Arthritis Drug shown to Stop Aggressive Cancer!

Nov 4, 2026 13 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:27 - Genetics and Mitochondria: Married7:50 - Reusing Old Medicine to Fight CancerReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1115] Un W, Hao C, Wang Z, et al. SWI/SNF subunit SMARCD1 deficiency promotes clear cell renal cell carcinoma progression via mitochondrial reprogramming. Nature Communications. Published online October 8, 2026. doi:10.1038/s41467-026-78285-3.[Study 1116] Bezwada D, Perelli L, Lesner NP, et al. Mitochondrial complex I promotes kidney cancer metastasis. Nature. 2024;633(8031):923–931. doi:10.1038/s41586-024-07812-3.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

These Two Molecules are Pushing Anti-Aging Science Forward!

Nov 2, 2026 7 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderAnti-Aging Series: https://www.youtube.com/playlist?list=PLwiri7XRU2i-HLExt7W-5qp_z2tIP_UvU0:00 - Introduction0:55 - Senolytics: An Advanced Future3:44 - Bone, Kidneys, Liver, and…5:57 - Molecules and ConsiderationsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1093] Hickson LJ, Langhi Prata LGP, Bobart SA, et al. Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease. EBioMedicine. 2019;47:446–456. doi:10.1016/j.ebiom.2019.08.069.[Study 1094] Farr JN, Atkinson EJ, Achenbach SJ, et al. Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial. Nat Med. 2024;30:2605–2612. doi:10.1038/s41591-024-03096-2.[Study 1095] Justice JN, Nambiar AM, Tchkonia T, et al. Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study. EBioMedicine. 2019;40:554–563. doi:10.1016/j.ebiom.2018.12.052.[Study 1096] Martyanov V, Whitfield ML, Varga J. Senescence signature in skin biopsies from systemic sclerosis patients treated with senolytic therapy: potential predictor of clinical response? Arthritis Rheumatol. 2019;71(10):1766–1767. doi:10.1002/art.40934.[Study 1097] Hambright WS, Duke VR, Goff AD, et al. Clinical validation of C12FDG as a marker associated with senescence and osteoarthritic phenotypes. Aging Cell. 2024;23. doi:10.1111/acel.14113.[...

‘An Incredibly Common Food That Melts Clogged Arteries (Most Eat Them Wrong)’

Oct 31, 2026 14 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:08 - Artery Damage: Origin of Plaque?5:20 - Lycopene reduces Oxidation9:12 - A 'Healthy' Fat?9:50 - Cardiovascular Disease Outcomes and Plaque Reversal12:55 - Main PointsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Constantinides P, Harkey M. Ann N Y Acad Sci. 1990;598:113–124. DOI: 10.1111/j.1749-6632.1990.tb42283.x[2] Faggiotto A, et al. Arteriosclerosis. 1984;4:323–340. DOI: 10.1161/01.ATV.4.4.323[3] Huang L, et al. Nature. 2019;569:565–569. DOI: 10.1038/s41586-019-1140-4[4] Juul K, et al. Circulation. 1996;94:1698–1704. DOI: 10.1161/01.CIR.94.7.1698[5] Chang MY, et al. J Lipid Res. 2001;42:824–833. DOI: 10.1016/S0022-2275(20)31645-X[6] Story EN, et al. Annu Rev Food Sci Technol. 2010;1:189–210. DOI: 10.1146/annurev.food.102308.124120[7] Ghaffari MA, Ghiasvand T. J Food Biochem. 2011;35:228–240. DOI: 10.1111/j.1745-4514.2010.00378.x[8] Romanchik JE, et al. J Nutr Biochem. 1997;8:681–688. DOI: 10.1016/S0955-2863(97)00119-8[Study 592] Sesso HD, et al. J Nutr. 2003;133:2336–2341. DOI: 10.1093/jn/133.7.2336[Study 587] Zou ZY, et al. Br J Nutr. 2014;111:474–480. DOI: 10.1017/S0007114513002730[9] Schwab US, et al. J Nutr. 1998;128:1703–1709. DOI: 10.1093/jn/128.10.1703[10] Lichtenstein AH, et al. Arterioscler Thromb. 1994;14:168–175. DOI: 10.1161/01.ATV.14.1.168[11] Kiecolt-Glaser JK, et al. Brain Behav Immun. 2012;26:988–995. DOI: 10.1016/j.bbi.2012.05.011[12] Dong Y, et al. Nutrients. 2022;14:5307. DOI: 10.3390/nu1...

Put these in your Ears and Protect your Brain!

Oct 29, 2026 4 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:29 - Long-term consequences4:28 - Social Isolation and More Considerations6:15 - A Disheartening Twist7:40 - Retwisting to a Heartening Twist, or something like that...8:54 - 24% Increased Risk10:04 - Use TheseReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)] [Study 346] Livingston et al. Dementia prevention and care: 2024 Lancet Commission. Lancet. 2024. [Study 1103] Yeo et al. Hearing devices, cognitive decline, and dementia: meta-analysis. JAMA Neurol. 2023. [Study 1104] Peribáñez García et al. Audiometric hearing loss, cognitive impairment, and dementia: meta-analysis. Am J Otolaryngol. 2026. [Study 1105] Lin et al. Hearing loss and cognitive decline in older adults. JAMA Intern Med. 2013. [Study 1106] Tai et al. Hearing impairment, hearing aids, and cognitive impairment: TLSA. BMC Geriatr. 2021. [Study 1107] Bucholc et al. Hearing aids, MCI-to-dementia conversion, and dementia progression. Alzheimers Dement (N Y). 2021. [Study 1108] Amieva et al. Hearing problems, mortality, depression, disability, and dementia: 25-year study. J Gerontol A. 2018. [Study 1109] Mahmoudi et al. Hearing aids and time to dementia, depression, or falls diagnosis. J Am Geriatr Soc. 2019. [Study 1110] Lin. Hearing loss and cognition in older US adults. J Gerontol A. 2011. [Study 1111] Davies et al. Hearing impairment and incident dementia: ELSA. J Am Geriatr Soc. 2017. [Study 1112] Chang et al. Hearing loss severity and dementia risk in Sout...

Dr. Rhonda Patrick: ‘Scientists discovered a Supplement that Repairs Aging Mitochondria!’

Oct 24, 2026 13 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderDr. Patrick's Video: https://www.youtube.com/shorts/1Du-MKJOjk80:00 - Introduction1:05 - It Clears out Old Mitochondria!4:30 - It Rejuvenates the Immune System!6:54 - VO2 Boost, Anti-Aging Benefits11:52 - A Huge Caveat!13:22 - Main PointsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Singh A, D'Amico D, Andreux PA, et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. Eur J Clin Nutr. 2022;76(2):297-308. doi:10.1038/s41430-021-00950-1 [2] Alpert A, Pickman Y, Leipold M, et al. A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring. Nat Med. 2019;25(3):487-495. doi:10.1038/s41591-019-0381-y [3] Imboden MT, Harber MP, Whaley MH, Finch WH, Bishop DL, Kaminsky LA. Cardiorespiratory fitness and mortality in healthy men and women. J Am Coll Cardiol. 2018;72(19):2283-2292. doi:10.1016/j.jacc.2018.08.2166. [6] Bailey SJ, Winyard P, Vanhatalo A, et al. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol (1985). 2009;107(4):1144-1155. doi:10.1152/japplphysiol.00722.2009[7] Lansley KE, Winyard PG, Bailey SJ, et al. Acute dietary nitrate supplementation improves cycling time trial performance. Med Sci Sports Exerc. 2011;43(6):1125-1131. doi:10.1249/MSS.0b013e31821597b4[8]...

Why is Cheese immune to raising Cardiovascular Disease risk?

Oct 22, 2026 9 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Analysis: https://www.youtube.com/watch?v=9i121BcPYlk&t=231s0:00 - Introduction1:03 - Assumptions make an Ass out of You and Me4:33 - The Matrix: Not the Movie6:57 - Keep this in mind...References [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1100] Feeney EL, Barron R, Dible V, et al. Dairy matrix effects: response to consumption of dairy fat differs when eaten within the cheese matrix—a randomized controlled trial. American Journal of Clinical Nutrition. 2018;108(4):667–674. doi:10.1093/ajcn/nqy146[Study 1101] Soerensen KV, Thorning TK, Astrup A, Kristensen M, Lorenzen JK. Effect of dairy calcium from cheese and milk on fecal fat excretion, blood lipids, and appetite in young men. American Journal of Clinical Nutrition. 2014;99(5):984–991. doi:10.3945/ajcn.113.077735[Study 1102] Rosqvist F, Smedman A, Lindmark-Månsson H, et al. Potential role of milk fat globule membrane in modulating plasma lipoproteins, gene expression, and cholesterol metabolism in humans: a randomized study. American Journal of Clinical Nutrition. 2015;102(1):20–30. doi:10.3945/ajcn.115.107045Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health...

TUDCA: A New Way of Addressing Insulin Resistance

Oct 19, 2026 9 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:50 - TUDCA2:59 - Mechanisms of Intrigue4:18 - TUDCA Results7:50 - Dosing & ConsiderationsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] She J, Tuerhongjiang G, Guo M, et al. Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner. Cell Metab. 2024;36(2):408–421.e5. doi:10.1016/j.cmet.2023.12.027.[2] Crosignani A, Battezzati PM, Cestari C, et al. Tauroursodeoxycholic acid for the treatment of chronic hepatitis: a multicentre dose-response study. Hepatol Res. 1998;13:10–19.[3] Ma H, Zeng M, Han Y, et al. A multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis. Medicine (Baltimore). 2016;95(47). doi:10.1097/MD.0000000000005391.[4] Pan XL, Zhao L, Li L, et al. Efficacy and safety of tauroursodeoxycholic acid in the treatment of liver cirrhosis: a double-blind randomized controlled trial. J Huazhong Univ Sci Technolog Med Sci. 2013;33(2):189–194. doi:10.1007/s11596-013-1095-x.[5] Poupon RE, Poupon R, Balkau B; UDCA-PBC Study Group. Ursodiol for the long-term treatment of primary biliary cirrhosis. N Engl J Med. 1994;330(19):1342–1347.[Study 1078] Kars M, Yang L, Gregor MF, et al. Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes. 2010;59(8):1899–1905. doi:10.2337/db10-0308.[Study 10...

The ‘Berberine Signature’: A New Heart Disease Protection Uncovered!

Oct 15, 2026 9 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - IntroductionYou talkin’ to me, ApoB?A Berberine Story: Genes, Associations, and TrialsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712–717. doi:10.1016/j.metabol.2008.01.013[Study 1076] Zhao JV, Sarsani V, Chen B, Yun H, Hu J, Liang L. Berberine signature and cardiometabolic diseases using randomized controlled trial, cohort study and Mendelian randomization. npj Cardiovasc Health. 2026;3(1):15. doi:10.1038/s44325-026-00113-w[Study 1077] Zhao JV, Chen B, Chan YH, et al. Sex-specific lipid, apolipoprotein B, and lipoprotein(a) responses to berberine based on 2 randomized placebo-controlled trials. JACC Asia. Published online July 11, 2026. doi:10.1016/j.jacasi.2026.06.011Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

15 Studies Later: Investigating Omega-3 Fats promoting Cancer

Oct 12, 2026 12 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:25 - The Study in Question2:05 - Worries Multiplied5:50 - A Counter-PunchReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1061] Aronson et al. J Clin Oncol. 2025. doi:10.1200/JCO.24.00608[Study 1062] Brasky et al. J Natl Cancer Inst. 2013. doi:10.1093/jnci/djt174[Study 1063] Brasky et al. Am J Epidemiol. 2011. doi:10.1093/aje/kwr027[Study 1064] Park et al. Cancer Causes Control. 2009. doi:10.1007/s10552-008-9236-4[Study 1065] Crowe et al. Am J Clin Nutr. 2008. doi:10.3945/ajcn.2008.26369[Study 1066] Chavarro et al. Cancer Epidemiol Biomarkers Prev. 2007. doi:10.1158/1055-9965.EPI-06-1033[Study 1067] Männistö et al. Cancer Epidemiol Biomarkers Prev. 2003. DOI not provided.[Study 1068] Harvei et al. Int J Cancer. 1997. doi:10.1002/(SICI)1097-0215(19970516)71:4%3C545::AID-IJC7%3E3.0.CO;2-U[Study 1069] Augustsson et al. Cancer Epidemiol Biomarkers Prev. 2003. DOI not provided.[Study 1070] Leitzmann et al. Am J Clin Nutr. 2004. doi:10.1093/ajcn/80.1.204[Study 1071] Chavarro et al. Am J Clin Nutr. 2008. doi:10.3945/ajcn.2008.26419[Study 1072] Brasky et al. Nutr Cancer. 2011. doi:10.1080/01635581.2011.553022[Study 1073] Torfadottir et al. PLoS One. 2013. doi:10.1371/journal.pone.0059799[Study 1074] Moreel et al. Cancer Prev Res (Phila). 2014. doi:10.1158/1940-6207.CAPR-13-0349[Study 1075] Outzen et al. Eur J Cancer Prev. 2018. doi:10.1097/CEJ.0000000000000330Please use the following link to submit your critique: https://b...

Bombshell Study Upends Low Carb Nutrition Science!

Oct 8, 2026 10 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderOriginal Prediction on Ketone Mechanism: https://www.youtube.com/watch?v=q-uG5lMwHlU&t=228s0:00 - Introduction1:20 - Finally!2:59 - Agreement across Studies?4:50 - The Carbohydrate Twist5:15 - Protein Inequality6:06 - Time Matters?7:18 - Revisiting my PredictionReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 518] Queathem ED, Stagg DB, Nelson AB, et al. Ketogenesis mitigates metabolic dysfunction–associated steatotic liver disease through mechanisms that extend beyond fat oxidation. J Clin Invest. 2025;135(12). doi:10.1172/JCI191021.[Study 1056] Petersen MC, Smith GI, Farabi SS, et al. Effect of diet macronutrient content on the cardiometabolic response to weight loss: a randomized clinical trial. Cell Metab. 2026;38:1–12. doi:10.1016/j.cmet.2026.07.020.[Study 1057] Qadri SF, Porthan K, Dufour S, et al. Distinct effects of ketogenic and non-ketogenic weight-loss diets on hepatic steatosis and mitochondrial metabolism in MASLD. J Hepatol. 2026;85:26–36. doi:10.1016/j.jhep.2026.02.001.[Study 1058] London A, Richter MM, Sjøberg KA, et al. The impact of short-term eucaloric low- and high-carbohydrate diets on liver triacylglycerol content in males with overweight and obesity: a randomized crossover study. Am J Clin Nutr. 2024;120:283–293. doi:10.1016/j.ajcnut.2024.06.006.[Study 1059] Kirk E, Reeds DN, Finck BN, et al. Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology. 2009;...

Oats, Heart Disease, and the Molecules within Oats

Oct 5, 2026 7 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Analysis: https://www.youtube.com/watch?v=c0Hm9tQ9zuc&t=1s0:00 - Introduction0:43 - Oats: Eat ‘em or Leave ‘em?1:52 - The Traditional3:10 - Something Suspicious about Oats…References[Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Zhang J, Li L, Song P, et al. Randomized controlled trial of oatmeal consumption versus noodle consumption on blood lipids of urban Chinese adults with hypercholesterolemia. Nutrition Journal. 2012;11:54. doi:10.1186/1475-2891-11-54.[2] Thongoun P, Pavadhgul P, Bumrungpert A, Satitvipawee P, Harjani Y, Kurilich A. Effect of oat consumption on lipid profiles in hypercholesterolemic adults. Journal of the Medical Association of Thailand. 2013;96 Suppl 5–S32.[Study 1002] Klümpen L, Mantri A, Philipps M, et al. Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial. Nature Communications. 2026;17:598. doi:10.1038/s41467-026-68303-9.[Study 1003] Xu D, Feng M, Chu Y, et al. The prebiotic effects of oats on blood lipids, gut microbiota, and short-chain fatty acids in mildly hypercholesterolemic subjects compared with rice: a randomized, controlled trial. Frontiers in Immunology. 2021;12:787797. doi:10.3389/fimmu.2021.787797.[Study 1004] Hu Y, Willett WC, Manson JE, et al. Intake of whole grain foods and risk of coronary heart disease in US men and women. BMC Medicine. 2022;20:192. doi:10.1186/s12916-022-02396-z.[Study 1005] Helnæs A, Kyrø...

4 Ways to Melt Visceral Fat!

Sep 28, 2026 8 min

JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 HEALTH AUTONOMY [COURSE]Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy JOIN THE COMMUNITYJoin my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 EMAIL LIST1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6 HIRE ME FOR CONSULTING:Consulting: https://bit.ly/3dmUl2H Created with Biorender 0:00 - Introduction1:22 - Option 12:20 - Option 23:55 - Option 35:55 - Option 4 References[1] Kadowaki T, et al. Obes Res Clin Pract. 2025;19(2):146-153. doi:10.1016/j.orcp.2025.03.003. [2] Wilding JPH, et al. J Endocr Soc. 2021;5(Suppl 1):A16-A17. doi:10.1210/jendso/bvab048.030. [3] Arciero PJ, et al. Obesity. 2023;31(Suppl 1):139-149. doi:10.1002/oby.23660. [4] Zuo L, et al. Front Physiol. 2016;7:350. doi:10.3389/fphys.2016.00350. [Study 396] Zelicha H, et al. BMC Med. 2022;20:327. doi:10.1186/s12916-022-02525-8. [Study 427] Kaplan A, et al. Am J Clin Nutr. 2022;115(5):1270-1281. doi:10.1093/ajcn/nqac001. [Study 780] Look M, et al. Diabetes Obes Metab. 2025;27(5):2720-2729. doi:10.1111/dom.16275. [Study 790] Falutz J, et al. J Clin Endocrinol Metab. 2010;95(9):4291-4304. doi:10.1210/jc.2010-0490. [Study 793] Makimura H, et al. J Clin Endocrinol Metab. 2012;97(12):4769-4779. doi:10.1210/jc.2012-2794. [Study 509] Di Tano M, et al. Nat Commun. 2020;11:2332. doi:10.1038/s41467-020-16243-3. [Study 510] Vernieri C, et al. Cancer Discov. 2022;12(1):90-107. doi:10.1158/2159-8290.CD-21-0030. [Study 511] Ligorio F, et al. Int J Cancer. 2024;154(1):114-123. doi:10.1002/ijc.34701. [Study 512] Vernieri C, et al. Cell Metab. 2024;36(8):1644-1667. doi:10.1016/j.cmet.2024.06.014. [Study 606] Ni Y, et al. Cell Metab. 2023;35(9):1530-1547. doi:10.1016/j.cmet.2023.08.002. [Study 607] Long X, et al. Cell Metab. 2025;37:2342-2361. doi:10.1016/j.cmet.2025.10.017. [Study 608] Li H, et al. Nat Metab. 2024;6(3):578-597. doi:10.1038/s42255-024-00988-y...

Dr. Fung: ‘Cholesterol is barely relevant to Heart Disease’

Sep 26, 2026 17 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction2:13 - Blood Cholesterol is not Important13:08 - Something else matters WAY more than Blood Cholesterol16:45 - Main PointsReferences[Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Khan SS, Matsushita K, Sang Y, et al. Development and validation of the American Heart Association’s PREVENT equations. Circulation. 2024;149:430–449. doi:10.1161/CIRCULATIONAHA.123.067626.[2] Dugani SB, Moorthy MV, Li C, et al. Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident coronary heart disease in women. JAMA Cardiol. 2021;6(4):437–447. doi:10.1001/jamacardio.2020.7073.[3] Magnussen C, Alegre-Diaz J, Al-Nasser LA, et al. Global effect of cardiovascular risk factors on lifetime estimates. N Engl J Med. 2025;393(2):125–138. doi:10.1056/NEJMoa2415879.[4] Blumenthal RS, Morris PB, Gaudino M, et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of dyslipidemia: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;153:e1154–e1276. doi:10.1161/CIR.0000000000001423.[5] Cannon CP, Blazing MA, Giugliano RP, et al; IMPROVE-IT Investigators. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med. 2015;372(25):2387–2397. doi:10.1056/NEJMoa1410489.[6] Nordestgaard BG, Langlois MR, Langsted A, et al. Quantifying atherogenic lipoproteins for lipid-lowering strategies: Consen...

Manipulating Vitamin D to fight Cancer! [New Research]

Sep 24, 2026 10 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender750% increased Pancreatic Cancer: https://www.youtube.com/watch?v=_YPIO9CBuw8&t=1s0:00 - Introduction0:25 - CAFs, Vitamin D Receptor, and Cancer3:41 - What happens?5:57 - Why are the results the way they are?8:00 - Vitamin D39:30 - My backlight died and ConclusionsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)] [Study 1045] Perez KJ, et al. Gemcitabine and nab-paclitaxel ± paricalcitol for metastatic pancreatic cancer. Nat Cancer. 2026;7:928–943. [Study 1046] Sherman MH, et al. Vitamin D receptor-mediated stromal reprogramming enhances pancreatic cancer therapy. Cell. 2014;159:80–93. [Study 1047] Grierson PM, et al. Paricalcitol plus nanoliposomal irinotecan and 5-FU/LV in advanced pancreatic cancer. Clin Cancer Res. 2023;29:4733–4739. [Study 1048] Chung V, et al. Pembrolizumab ± paricalcitol in metastatic pancreatic cancer. Oncologist. 2025;30. [Study 1049] Easty D, et al. Paricalcitol with gemcitabine and nab-paclitaxel in advanced pancreatic cancer. BMC Cancer. 2026;26:255. [Study 1050] Viniotis AF, et al. NABPLAGEM and paricalcitol as neoadjuvant therapy in pancreatic cancer. Oncologist. 2026;31. [Study 1051] Rasmussen LS, et al. Vitamin D deficiency, inflammation, and survival in pancreatic cancer. Eur J Cancer. 2021;144:72–80. [Study 1052] Yuan C, et al. Prediagnostic 25-hydroxyvitamin D and pancreatic cancer survival. J Clin Oncol. 2016;34:2899–2905. [Study 1053] Cho M, et al. Vitamin D deficiency and prognosis in pancreatic adenocar...

The Mortality Effect of Walnuts are Hard to Ignore - Why?

Sep 21, 2026 9 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Walnut-Mortality Analysis: https://www.youtube.com/watch?v=3DqCZZgDdF8&t=337s0:00 - Introduction0:45 - It’s a Meee, Cholesterol!3:15 - You heard me, I called you Endothelial5:12 - A New View of Inflammation7:35 - How much to eat?References [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1037] Rajaram S, Cofán M, Sala-Vila A, et al. Effects of walnut consumption for 2 years on lipoprotein subclasses among healthy elders: findings from the WAHA randomized controlled trial. Circulation. 2021;144:1083-1085. doi:10.1161/CIRCULATIONAHA.121.054051.[Study 1038] Wu L, Piotrowski K, Rau T, et al. Walnut-enriched diet reduces fasting non-HDL-cholesterol and apolipoprotein B in healthy Caucasian subjects: a randomized controlled cross-over clinical trial. Metabolism. 2014;63:382-391. doi:10.1016/j.metabol.2013.11.005.[Study 1039] Ros E, Núñez I, Pérez-Heras A, et al. A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation. 2004;109:1609-1614. doi:10.1161/01.CIR.0000124477.91474.FF.[Study 1040] Katz DL, Davidhi A, Ma Y, et al. Effects of walnuts on endothelial function in overweight adults with visceral obesity: a randomized, controlled, crossover trial. J Am Coll Nutr. 2012;31(6):415-423.[Study 1041] Berryman CE, Grieger JA, West SG, et al. Acute consumption of walnuts and walnut components differentially affect postprandial lipemia, endothelial function, oxidative stress, and cholesterol...

A New Discovery: Serine, Stress, and Insulin Resistance

Sep 17, 2026 13 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:59 - You’re Stressin’ Me, Man, my Glucose is High!5:21 - Not all roads lead to Serine6:10 - A Serine StoryReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1032] He A, Zhu Y, Liang C, et al. Amygdala astrocyte senescence drives stress-induced anxiety and hyperglycemia. Cell Metab. 2026;38:1385-1403. doi:10.1016/j.cmet.2026.03.006.[Study 1033] Roberts AL, Agnew-Blais JC, Spiegelman D, et al. Posttraumatic stress disorder and incidence of type 2 diabetes mellitus in a sample of women: a 22-year longitudinal study. JAMA Psychiatry. 2015;72(3):203-210. doi:10.1001/jamapsychiatry.2014.2632.[Study 1034] Vaccarino V, Goldberg J, Magruder KM, et al. Posttraumatic stress disorder and incidence of type-2 diabetes: a prospective twin study. J Psychiatr Res. 2014;56:158-164. doi:10.1016/j.jpsychires.2014.05.019.[Study 1035] Nowotny B, Cavka M, Herder C, et al. Effects of acute psychological stress on glucose metabolism and subclinical inflammation in patients with post-traumatic stress disorder. Horm Metab Res. 2010;42:746-753. doi:10.1055/s-0030-1261924.[Study 1036] Heresco-Levy U, Vass A, Bloch B, et al. Pilot controlled trial of D-serine for the treatment of post-traumatic stress disorder. Int J Neuropsychopharmacol. 2009;12:1275-1282. doi:10.1017/S1461145709000339.Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Peptides with HUGE Cardiovascular Impact!

Sep 14, 2026 10 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:18 - Peptides on Cardiovascular Disease3:09 - Peptides on Reversing Arterial Plaque6:58 - There is hope...References [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)] [Study 1018] Marso SP, et al. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016. doi:10.1056/NEJMoa1607141. [Study 1019] Gerstein HC, et al. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND). Lancet. 2019. doi:10.1016/S0140-6736(19)31149-3. [Study 1020] Gerstein HC, et al. The effect of dulaglutide on stroke: an exploratory analysis of REWIND. Lancet Diabetes Endocrinol. 2020. doi:10.1016/S2213-8587(19)30423-1. [Study 1021] Hernandez AF, et al. Albiglutide and cardiovascular outcomes in type 2 diabetes and cardiovascular disease. Lancet. 2018. doi:10.1016/S0140-6736(18)32261-X. [Study 1022] Lincoff AM, et al. Semaglutide and cardiovascular outcomes in obesity without diabetes. N Engl J Med. 2023. doi:10.1056/NEJMoa2307563. [Study 1023] McGuire DK, et al. Oral semaglutide and cardiovascular outcomes in high-risk type 2 diabetes. N Engl J Med. 2025. doi:10.1056/NEJMoa2501006. [Study 1024] Gitto M, et al. GLP-1 receptor agonists and coronary plaque regression after acute coronary syndromes. Acta Diabetol. 2026. doi:10.1007/s00592-025-02606-z. [Study 1025] Kataoka Y, et al. GLP-1 analogues and delipidation of coronary atheroma. Atheroscler Plus. 2024. doi:10.1016/j.athplu.2024.03.001. [Study 1026] Heinsen LJ, et...

Dr. Mason: Fiber’s Health Benefits are Built on FLAWED Research!

Sep 12, 2026 14 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:09 - No Good Research on Health Effects of Fiber5:21 - This is what we Need!8:08 - Whoops.. Hypocrisy? 12:50 - Main PointsReferences [1] Park Y, Subar AF, Hollenbeck A, Schatzkin A. Dietary fiber intake and mortality in the NIH-AARP diet and health study. Arch Intern Med. 2011;171(12):1061-1068. doi:10.1001/archinternmed.2011.18[2] Chuang SC, Norat T, Murphy N, et al. Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort. Am J Clin Nutr. 2012;96(1):164-174. doi:10.3945/ajcn.111.028415[3] Buil-Cosiales P, Zazpe I, Toledo E, et al. Fiber intake and all-cause mortality in the Prevención con Dieta Mediterránea (PREDIMED) study. Am J Clin Nutr. 2014;100(6):1498-1507. doi:10.3945/ajcn.114.093757[4] Li S, Flint A, Pai JK, et al. Dietary fiber intake and mortality among survivors of myocardial infarction: prospective cohort study. BMJ. 2014;348. doi:10.1136/bmj.g2659[5] Katagiri R, Goto A, Sawada N, et al. Dietary fiber intake and total and cause-specific mortality: the Japan Public Health Center-based prospective study. Am J Clin Nutr. 2020;111(5):1027-1035. doi:10.1093/ajcn/nqaa002[6] Burn J, Bishop DT, Mecklin JP, et al. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome. N Engl J Med. 2008;359(24):2567-2578. doi:10.1056/NEJMoa0801297[7] Robertson MD, Bickerton AS, Dennis AL, Vidal H, Frayn KN. Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue me...

Aging Genes can be Turned Off, if you do This Regularly

Sep 10, 2026 8 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:48 - Freezing Aging through Exercise4:18 - The Exercise Methylome7:02 - A Bit Gene CrazyReferences[Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1006] Janssens GE, Trętowicz MM, Grevendonk L, et al. Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle. Nat Aging. 2026;6:1482-1500. doi:10.1038/s43587-026-01150-x.[Study 1007] Voisin S, Seale K, Jacques M, et al. Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle. Aging Cell. 2024;23:e13859. doi:10.1111/acel.13859.[Study 1008] Melov S, Tarnopolsky MA, Beckman K, Felkey K, Hubbard A. Resistance exercise reverses aging in human skeletal muscle. PLoS One. 2007;2(5):e465. doi:10.1371/journal.pone.0000465.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Berberine: A Powerful New Metabolic Mechanism Discovered!

Sep 7, 2026 8 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:15 - The Classics1:57 - What’s the News?6:04 - BerberineReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Dong H, Wang N, Zhao L, Lu F. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med. 2012;2012:591654. doi:10.1155/2012/591654[Study 985] Sebo ZL, Chakrabarty RP, Grant RA, D’Alessandro KB, Koss AR, Blum JLE, et al. Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycaemic control. Nat Metab. 2026;8:1291-1304. doi:10.1038/s42255-026-01530-y[Study 986] Koffert JP, Mikkola K, Virtanen KA, Andersson AMD, Faxius L, Hällsten K, et al. Metformin treatment significantly enhances intestinal glucose uptake in patients with type 2 diabetes: results from a randomized clinical trial. Diabetes Res Clin Pract. 2017;131:208-216. doi:10.1016/j.diabres.2017.07.015[Study 987] Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes. Metabolism. 2008;57(5):712-717. doi:10.1016/j.metabol.2008.01.013Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

‘They Lied about High LDL!’ - The Corrupt Science behind Heart Disease

Sep 5, 2026 28 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Original Podcast: https://youtu.be/q57CNySsYxs?si=PIwVEVGj_-cYkDCU0:00 - Introduction1:54 - Genetics that cause High Cholesterol5:29 - The American Heart Association is lying to you8:05 - Extremely High Cholesterol doesn't Kill17:48 - High Cholesterol at 60? Protection from Death25:20 - Other ways of testing this?27:12 - Main PointsReferences[1] Mundal L, Sarancic M, Ose L, et al. Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992–2010. *J Am Heart Assoc*. 2014;3(6):e001236. doi:10.1161/JAHA.114.001236[2] Brown MS, Goldstein JL. Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. *Proc Natl Acad Sci U S A*. 1974;71(3):788-792. doi:10.1073/pnas.71.3.788[3] Shishikura D, Harada-Shiba M, Michikura M, et al. Comparison of clinical characterization and therapeutic strategies between homozygous familial hypercholesterolemia and heterozygous familial hypercholesterolemia. *J Atheroscler Thromb*. 2026;33. Advance publication online March 27, 2026. doi:10.5551/jat.65959[4] Wiegman A, de Groot E, Hutten BA, et al. Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia. *Lancet*. 2004;363(9406):369-370. doi:10.1016/S0140-6736(04)15467-6[5] EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collab...

Peptides with HUGE Cardiovascular Impact: New Mechanism Discovered!

Sep 1, 2026 8 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Analysis: https://www.youtube.com/watch?v=e2_9mHtWwBQ0:00 - Introduction0:36 - Peptides on Cardiovascular Disease1:25 - Ceramides!3:44 - One Ceramide to instill Fear in All!6:16 - Returning to PeptidesReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1022] Lincoff AM, Brown-Frandsen K, Colhoun HM, et al; SELECT Trial Investigators. Semaglutide and cardiovascular outcomes in obesity without diabetes. N Engl J Med. 2023;389(24):2221-2232. doi:10.1056/NEJMoa2307563[Study 998] Lundgren JR, Janus C, Jensen SBK, et al. Healthy weight loss maintenance with exercise, liraglutide, or both combined. N Engl J Med. 2021;384(18):1719-1730. doi:10.1056/NEJMoa2028198[Study 999] Sandsdal RM, Holt J, Alkhefagie HGA, et al. Effects of exercise and liraglutide on vascular health and inflammation during weight loss maintenance: a prespecified secondary analysis of the S-LiTE trial. Nat Metab. 2026;8:1483-1488. doi:10.1038/s42255-026-01554-4[Study 1000] Mashayekhi M, Beckman JA, Nian H, et al. Comparative effects of weight loss and incretin-based therapies on vascular endothelial function, fibrinolysis, and inflammation in individuals with obesity and pre-diabetes: a randomized, controlled trial. Diabetes Obes Metab. 2023;25(2):570-580. doi:10.1111/dom.14903.[Study 1001] Akawi N, Checa A, Antonopoulos AS, et al. Fat-secreted ceramides regulate vascular redox state and influence outcomes in patients with cardiovascular disease. J Am Coll Cardiol. 2021;7...

Glycine Restriction for Cancer, Berberine against Colorectal Cancer, and More

Apr 20, 2026 3 hr 40 min

Collagen for Skin 'Debunked, Non-Nutritive Sweeteners on Cognitive Decline, Seed Oils, and More

Oct 25, 2025 3 hr 5 min

Age Reversing Antibodies, Glycine and Longevity, Ergothioneine and Mitochondria, and More

Sep 21, 2024 3 hr 31 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More *HEALTH AUTONOMY [COURSE]* Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy *JOIN THE COMMUNITY* Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* One Weekly Email of Value: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H *DONATIONS FOR A SCIENCE BASED CAUSE* Patreon: https://bit.ly/PhysionicPatreon *OTHER SOCIAL MEDIA* Instagram: http://bit.ly/2OBFe7i

Reversing Heart Disease, Creatine on Kidney Health, 5 Life Extending Habits, and More

May 4, 2024 5 hr 3 min

Oreos lowering Blood Cholesterol, Science Communication, Mechanisms of Heart Disease, Ft. Dr. Norwitz, Dave Feldman

Mar 16, 2024 3 hr 16 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More *JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST*One Weekly Email of Value: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H *DONATIONS FOR A SCIENCE BASED CAUSE*Patreon: https://bit.ly/PhysionicPatreon *OTHER SOCIAL MEDIA*Instagram: http://bit.ly/2OBFe7i Nick's Channel: https://youtu.be/yiq67wpUhIs?si=AAercNmT4OX6fk_z Dave's Channel: https://youtu.be/RzG6N8WWufM?si=XNl6HTJ66vUpZ0QT 0:00 - Introduction of Study 3:47 - Introduction to Dr. Nick Norwitz and Dave Feldman 8:31 - Dr. Norwitz details the Oreo Study 31:52 - Problems with Science Communication 1:12:42 - Discussion with Dave Feldman 1:15:20 - Lipid Heart Model of Heart Disease 1:27:28 - Lean Mass Hyper-Responders 1:35:10 - Mechanisms of Action Discussion

Dr. Brad Stanfield: A Discussion of Supplements for Longevity and Health

Dec 18, 2023 53 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT] *Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More *JOIN THE COMMUNITY* Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* One Weekly Email of Value: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H *DONATIONS FOR A SCIENCE BASED CAUSE* Patreon: https://bit.ly/PhysionicPatreon *OTHER SOCIAL MEDIA* Instagram: http://bit.ly/2OBFe7i Dr. Stanfield's Channel: https://www.youtube.com/@DrBradStanfield Timestamps 0:00 – Introduction 1:05 – Nicotinamide Mononucleotide (NMN) 17:14 – Creatine 20:25 – Collagen Peptides 25:58 – Thoughts on Meta-Analyses 29:18 – Hyaluronic Acid 34:08 – Taurine 37:42 – Thoughts on Mouse Studies 39:55 – Do Blood Markers Matter for Longevity? 42:29 – Trusting Science/Experts 44:05 – Dr. Stanfield’s Motivations for Clinical Education 53:12 – Ending Remarks

Reconsidering Aging, Muscle Growth, Niacin Supplementation, Your Questions, and More

Nov 19, 2023 3 hr 58 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More *JOIN THE COMMUNITY* Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* One Weekly Email of Value: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H *DONATIONS FOR A SCIENCE BASED CAUSE* Patreon: https://bit.ly/PhysionicPatreon *OTHER SOCIAL MEDIA* Instagram: http://bit.ly/2OBFe7i 0:00 - Introduction 5:11 - How to think about Aging 33:48 - Oxidized Blood Lipoproteins 58:34 - Study shows Age Reversal 1:15:28 - Oxalates 1:28:28 - Creatine as a Nootropic 1:35:48 - Niacin and Heart Disease 2:13:17 - Methylene Blue 2:25:25 - NMN on Health 2:38:46 - Inflammation contributing to Heart Disease 2:50:39 - Understanding Cellular Energy for Muscle Growth 3:07:08 - Subscriber Questions & Comments 3:42:05 - Housekeeping

Carnivore Diet, LDL Cholesterol, Fasting & Inflammation, Taurine on Longevity, and much more...

Jul 28, 2023 3 hr 3 min

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders [Premium]: https://bit.ly/PhysionicInsiders *JOIN THE COMMUNITY* Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity Table of Content 0:00 - Introduction 05:18 - Carnivore Diet 34:39 - LDL Cholesterol & Heart Disease 1:00:11 - Taurine on Longevity & Health 1:13:04 - One Meal a Day - Context Matters 1:22:27 - Fiber - Good or Bad? Mixed Reviews... 1:38:10 - Cancer is a Metabolic Disease? 2:07:10 - Fasting raises Inflammation!? 2:16:52 - Q&A 2:37:23 - Stories of Health Success 2:44:22 - My PhD Progress, Life outside of University

Insulin on Fat Loss, GlyNAC for Anti-Aging, The Physionic Dream.

Mar 18, 2023 2 hr 46 min

JOIN MY PHYSIONIC SOCIAL NETWORK Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity Join the Physionic Insiders [Premium]: https://bit.ly/PhysionicInsiders HIRE ME FOR CONSULTING: https://bit.ly/3dmUl2H DONATIONS FOR A SCIENCE BASED CAUSE Patreon: patreon.com/PhysionicPhD WHERE ELSE IM ACTIVE: Email: http://bit.ly/2AXIzK6 Podcast: http://bit.ly/2PThKz0 Instagram: http://bit.ly/2OBFe7i 0:00 – Introduction. 5:30 – Toxic Acrylamides in Coffee. 18:46 – The Physionic Dream. 50:05 – Sucralose and Insulin Sensitivity. 57:00 – Insulin & Body Fat. 1:23:25 – Carbohydrate-Insulin Model of Obesity. 2:17:35 – GlyNAC for Anti-Aging. 2:29:50 – Hyaluronic Acid on Skin Aging. 2:40:45 – The Future Content.

Removing my John Campbell Video, High Intensity Health, Sweeteners break your Fast?, and More.

Nov 5, 2022 1 hr 21 min

JOIN MY PHYSIONIC SOCIAL NETWORK Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity Join the Physionic Insiders [Premium]: https://bit.ly/PhysionicInsiders HIRE ME FOR CONSULTING: https://bit.ly/3dmUl2H WHERE ELSE IM ACTIVE: Email: http://bit.ly/2AXIzK6 Podcast: http://bit.ly/2PThKz0 Instagram: http://bit.ly/2OBFe7i 0:00 - Introduction. 3:00 - Dr. John Campbell, High Intensity Health. 39:40 - Nutrition Gurus. 53:00 - My Investigation on Non-Nutritive Sweeteners. 1:03:05 - Improving the 'Detailed Study Analyses'. 1:09:53 - Sweeteners break your Fast? 1:14:23 - Alternate Day Fasting.

My High Blood Pressure Experience; Plastics impact on Insulin Resistance.

Jun 26, 2022 1 hr 30 min

Hi, in this episode, I cover a bunch of topics from my experience at the doctor, my own hypocrisy, some things I learned from you, and finally - the main topic of discussion: Insulin resistance and how plastics (phthalates) affect it. Oh, and if you're on Spotify or YouTube, it's now a video podcast, as well! MY COURSES, INSIDERS COMMUNITY, & CONSULTING - Join the ‘Physionic Insiders’ (Exclusive Content): https://www.patreon.com/PhysionicPhD - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

Issues with Nutrition Documentaries; Caffeine and Performance - They Don't Always Mix.

May 28, 2022 1 hr 25 min

Hi folks, in this episode I unintentionally discussed two topics. One, I planned on discussing, which was caffeine and it's performance effects in weight lifting and endurance. However, because I woke myself up to a nutrition documentary that I watched for 20 minutes or so before recording, I felt I had to get some things off my chest related to the second topic - nutrition documentaries. So, you have the distinct pleasure (or dismay) of listening to me ramble on both, but I hope that either way you learn something of use, especially related to caffeine. MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Video and Studies on Caffeine: https://youtu.be/9WTbwlU5yOs

Nutrition & Pharmaceutical Therapies: Fat related Cancers

Apr 14, 2022 1 hr 26 min

In this episode, the first of a more relaxed, long form podcast style, we're going to dive into how fat relates to cancers - the mechanisms, but beyond that, the different therapies employed by pharmaceuticals, along with the use of nutrition to combat certain cancers. MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Related Videos: Mechanisms: https://youtu.be/Ijt1lqxn2AQ Therapies: https://youtu.be/iLdcoIIiByo Scientific Review: Reprogramming of Fatty Acid Metabolism in Cancer British Journal of Cancer

Let's Change how We do Things Here.

Mar 31, 2022 14 min

I think you'd be better served if we change how we do things on the Physionic Podcast. MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

Carbohydrates slow Metabolism and Mitochondrial Breathing.

Mar 25, 2022 19 min

In this episode, I'm going to begin the explanation as to what effects carbohydrates have on our metabolism, and one potential effect in our mitochondria. Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs34%5D-a-high-carbohydrate-diet-lowers-the-rate-of-adipose-tissue-mitochondrial-respiration Video: https://www.youtube.com/watch?v=7uBHNUSI6hI Previous Video on Carbs and Metabolism: https://www.youtube.com/watch?v=xn8VJzGCK5U&t=2s MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Study: A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration Benjamin Bikman

An Exception to the Insulin Sensitivity Effects of Saturated Fat [Study 31]

Mar 18, 2022 28 min

In this episode, we'll discuss a potential exception to the negative results on insulin sensitivity we've been discussing with the exposure to saturated fat. Study, Notes, & Amendments: https://www.physionic.org/examine/%5B31%5D-palmitate-acutely-induces-insulin-resistance-in-isolated-muscle-from-obese-but-not-lean-humans Video: https://youtu.be/ldUBG4-EJDo MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Study: Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans. A Brianne Thrush

Mitochondria & Diabetes: How Nutrition Connects the Two. [Study 32]

Mar 10, 2022 29 min

Hi all, in this episode, I'm going to describe to you how your nutrition, generally, affects your mitochondria in diabetes specific cells and how long term habits in nutrition can lead to diabetes (type 2). Enjoy. Video Version: https://youtu.be/x6EOhTzVKsE Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs32%5D-mitochondrial-dynamics-in-the-regulation-of-nutrient-utilization-and-energy-expenditure MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Study: Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure Marc Liesa

Your Nutrition affects your Mitochondria (Fasting vs Overconsumption) [Study 32]

Mar 3, 2022 35 min

In this episode, we'll be diving into two ways your mitochondria change their "behavior" to the exposure to different nutrition situations (high vs low nutrient presence). Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs32%5D-mitochondrial-dynamics-in-the-regulation-of-nutrient-utilization-and-energy-expenditure Video: https://www.youtube.com/watch?v=KQBmtzT4VTU MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Study: Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure Marc Liesa

Saturated vs Unsaturated Fats: One is Worse for Insulin Resistance [Study 30]

Feb 18, 2022 42 min

In this episode, we'll be going over a new study that wanted to find out the effects a saturated fat heavy consumption would have on insulin resistance and signaling against an unsaturated fat heavy consumption. Video: https://youtu.be/QfII7CANt14 Study: https://www.physionic.org/examine/%5Bs30%5D-dietary-palmitate-and-oleate-differently-modulate-insulin-sensitivity-in-human-skeletal-muscle MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Sarabhai, T., Koliaki, C., Mastrototaro, L., Kahl, S., Pesta, D., Apostolopoulou, M., Wolkersdorfer, M., Bönner, A. C., Bobrov, P., Markgraf, D. F., Herder, C., & Roden, M. (2022). Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle. Diabetologia, 65(2), 301–314. https://doi.org/10.1007/s00125-021-05596-z

Unsaturated Fat to the Rescue: Insulin Signaling and Mitochondrial Health [Study 28]

Feb 10, 2022 44 min

In this episode, we continue our quest for understanding the effect saturated fats have on muscle insulin signaling and mitochondrial health - however, beyond that, we'll be looking at how unsaturated fats may protect against the deleterious effects of saturated fat? Let's see.. Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs28%5D-different-effects-of-oleate-vs.-palmitate-on-mitochondrial-function%2C-apoptosis%2C-and-insulin-signaling-in-l6-skeletal-muscle-cells%3A-role-of-oxidative-stress- Video: https://youtu.be/TiO16KoH0Fs Study Title: Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Larysa Yuzefovych

Saturated Fat - Friend or Foe for Insulin Sensitivity and Mitochondrial Function? [Study 27]

Feb 4, 2022 23 min

In this episode, I'm kicking off a new format that's more tailored to the podcast listeners, so there's less need to head to the video versions of the podcast to understand half of what I'm talking about. In this episode, we'll be discussing saturated fat (palmitate) and it's effects in relation to insulin signaling in muscle cells, as well as mitochondrial function. What are the effects? What are the implications? Video: https://youtu.be/zMkV91E2Bic Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249685/

Body Fat is lost from THIS - NOT HORMONES

Nov 4, 2021 41 min

In this episode, I attempt to make sense of calories in vs out and reconcile that with the hormone argument for fat loss. Video Podcast: https://youtu.be/x1ZjjDzCdc0 MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

THIS is how Mitochondria DESTROY your Cells.

Oct 28, 2021 22 min

Mitochondria have a dark side, find out how. Video Podcast: https://www.youtube.com/watch?v=HPx7cv1I7eU MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

Long Term Effects from Fat Loss - Hormones, Weight Regain? [Study Breakdown]

Oct 14, 2021 38 min

In this podcast, we look at a study that investigates how weight loss affects hormones and long term weight regain - is the deck stacked against you? Study: https://www.nejm.org/doi/full/10.1056/nejmoa1105816 Video Podcast: https://youtu.be/-t5d0S5MRwE 0:00 - Introduction 2:47 - Study Design 6:58 - Weight Loss & Weight Regain Results 9:45 - Long Term Hormonal Changes from Weight Loss 34:12 - Conclusions/Take Aways MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

Does Intermittent Fasting, WITHOUT WEIGHT LOSS, improve your Health? [Study Breakdown]

Oct 6, 2021 26 min

How does intermittent fasting affect your health, even when you do not lose weight with it? Let's find out. Study: https://pubmed.ncbi.nlm.nih.gov/29754952/#:~:text=Men%20with%20Prediabetes-,Early%20Time%2DRestricted%20Feeding%20Improves%20Insulin%20Sensitivity%2C%20Blood%20Pressure%2C,Cell%20Metab. Video Podcast: https://youtu.be/1t0HUSlFNiQ MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 0:00 - Introduction 3:23 - Study Design 9:03 - Intermittent Fasting on Health Results 18:24 - "Fasting Increases Inflammation" 20:08 - Intermittent Fasting on Health Continued 23:00 - Conclusions/Take Aways

You asked for it: My Lifetime Workout Routine, Health Habits, and Supplements

Sep 22, 2021 40 min

Title says it all... Video Podcast: https://youtu.be/u4XirePJKfg MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

Sirtuins, Mitochondria, and Insulin Resistance

Sep 15, 2021 46 min

In this episode, we'll be discussing how sirtuins play their role in mitochondrial health and insulin resistance. Scientific Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432223/ Video Podcast: https://youtu.be/M9INrzrfsu4 0:00 - Introduction 3:10 - Diabetes Background 8:30 - Mitochondria Background 13:33 - Mitochondria & Insulin Resistance 20:33 - Sirtuins 43:40 - Conclusions/Take Aways MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6